MRE11 Polyclonal Antibody Store at -20°C
SKU: E-AB-11403-200
MRE11 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11403 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human MRE11A |
| Abbre | MRE11A |
| Synonyms | AT like disease, ATLD, Ataxia telangiectasia disorder like, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, HNGS1, endo/exonuclease Mre11, meiotic recombination (S. cerevisiae) 11 homolog |
| Swissprot | |
| Calculated MW | 81 kDa |
| Cellular Localization | Nucleus. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
Background
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.