MICU1 Monoclonal Antibody
SKU: E-AB-22114-200
MICU1 Monoclonal Antibody
| SKU # | E-AB-22114 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | WB, IHC-p, IF |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p, IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein |
| Abbre | MICU1 |
| Synonyms | Allergen Hom s 4, Atopy-related autoantigen CALC, CALC, Calcium uptake protein 1, Calcium-binding atopy-relate, ara CALC, atopy related autoantigen, atopy related autoantigen CALC, calcium binding atopy related autoantigen 1, calcium uptake protein 1, mitochondrial |
| Swissprot | |
| Observed MW | 55 kDa |
| Cellular Localization | Mitochondrion inner membrane. |
| Tissue Specificity | Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Metabolism, Immunology, Signal Transduction |
| Clone No. | 4E7 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:200 |
| IF | 1:100-1:300 |
Background
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. MICU1 (Mitochondrial Calcium Uptake 1) is a Protein Coding gene. Diseases associated with MICU1 include Myopathy With Extrapyramidal Signs and Fish Allergy. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3.