MAPK8 Polyclonal Antibody
SKU: E-AB-52157-200
MAPK8 Polyclonal Antibody
| SKU # | E-AB-52157 |
| Reactivity |
Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human MAPK8 |
| Abbre | MAPK8 |
| Synonyms | AI849689, C-JUN kinase 1, EC 2.7.11.24, JNK, JNK 1, JNK-46, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MK08, Mitogen activated protein kinase 8, Mitogen-activated protein kinase 8, Prkm8, Protein kinase , c Jun N terminal kinase 1, c-Jun N-terminal kinase 1, mapk8, p54 gamma |
| Swissprot | |
| Calculated MW | 48 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytosol, Mitochondrion, Nucleus, nucleoplasm, nucleus, Other locations: axon, basal dendrite, cytoplasm, neuron projection. |
| Concentration | 1.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-1:5000 |
Background
MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1,PRKM8,SAPK1,SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73,mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.