LRAT Polyclonal Antibody Reactivity Human
SKU: E-AB-53099-200
LRAT Polyclonal Antibody Reactivity Human
| SKU # | E-AB-53099 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human LRAT |
| Abbre | LRAT |
| Synonyms | LCA14, LRAT, Lecithin retinol acyltransferase, Lecithin retinol acyltransferase (phosphatidylcholine retinol O acyltransferase), Phosphatidylcholine retinol O acyltransferase, Phosphatidylcholine--retinol O-acyltransferase |
| Swissprot | |
| Cellular Localization | Endoplasmic reticulum membrane. Rough endoplasmic reticulum. Endosome>multivesicular body. Cytoplasm>perinuclear region. Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells. |
| Concentration | 0.78 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Metabolism, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:100 |
Background
The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants.