(KO Validated) EGFR Polyclonal Antibody
SKU: E-AB-93331-200
(KO Validated) EGFR Polyclonal Antibody
| SKU # | E-AB-93331 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | A synthetic peptide of human EGFR |
| Abbre | EGFR |
| Synonyms | ERBB, ERBB1, HER1, NISBD2, PIG61, epidermal growth factor receptor, mENA, EGFR |
| Swissprot |
P00533
|
| Calculated MW | 44 kDa/69 kDa/77 kDa/134 kDa |
| Observed MW | 175 kDa
The actual band is not consistent with the expectation.
|
| Cellular Localization | Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.