JNK2 Polyclonal Antibody Store at -20°C
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JNK2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15735 |
| Reactivity | Human , Mouse , Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human , Mouse , Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MAPK9 |
| Abbre | JNK2 |
| Synonyms | C Jun N terminal kinase 2, JNK 55, JNK-55, JNK2, JNK2 alpha, JNK2 beta, JNK2A, JNK2B, JNK2BETA, JNK2alpha, Jun kinase, MAP kinase 9, MAPK 9, MK09, Mapk9, Mitogen activated protein kinase 9, Mitogen-activated protein kinase 9, P54a, c Jun kinase 2, c-Jun N-terminal kinase 2 |
| Swissprot | |
| Calculated MW | 48 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytosol, Mitochondrion, Nucleus, nucleoplasm, nucleus, Other locations: cytoplasm, neuron projection. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:25-1:100 |
Background
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.