JAM-A Polyclonal Antibody Store at -20°C
SKU: E-AB-11338-200
JAM-A Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11338 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human F11R |
| Abbre | JAM-A |
| Synonyms | CD 321, CD321, CD321 antigen, ESTM33, F11 receptor, F11R, JAM, JAM 1, JAM A, JAM-1, JAM-A, JAM1, JAMA, JCAM, Jcam1, Junction adhesion molecule, Junction adhesion molecule 1, Junctional adhesion molecule 1, Junctional adhesion molecule A, KAT, Ly106, PAM, homolog of, mouse |
| Swissprot | |
| Calculated MW | 33 kDa |
| Cellular Localization | Cell junction>tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.