IRGM Polyclonal Antibody Store at -20°C
SKU: E-AB-11336-200
IRGM Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11336 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human IRGM |
| Abbre | IRGM |
| Synonyms | IFI1, IRGM, IRGM1, Iigp3, Iipg3, Immunity related GTPase family, Immunity related GTPase family M protein 1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon inducible protein 1, Interferon-inducible protein 1, Irgm, M |
| Swissprot | |
| Cellular Localization | Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle>phagosome membrane. Cytoplasmic vesicle>autophagosome membrane. Cell projection>phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Immunology, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.