ILF3 Polyclonal Antibody Reactivity Human
SKU: E-AB-52821-200
ILF3 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52821 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ILF3 |
| Abbre | ILF3 |
| Synonyms | ILF, MMP, Mpp, DRBP, NF-AT, MPHOSPH, TCP, ILF3, CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80, Double stranded RNA binding protein 76, Double-stranded RNA-binding protein 76, Interleukin enhancer binding factor 3, Interleukin enhancer-binding factor 3, M phase phosphoprotein 4, M-phase phosphoprotein 4, NF AT 90, Nuclear factor associated with dsRNA, Nuclear factor of activated T cells 90 kDa, Nuclear factor of activated T-cells 90 kDa, Translational control protein 80 |
| Swissprot | |
| Cellular Localization | Nucleus>nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Concentration | 0.72 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:300 |
Background
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.