IL12B Polyclonal Antibody
SKU: E-AB-19816-200
IL12B Polyclonal Antibody
| SKU # | E-AB-19816 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IL12B |
| Abbre | IL12B |
| Synonyms | IL-12/IL-23 p, IL-12 subunit p, NK cell stimulatory factor chain, NK cell Stimulating Factor Chain, CLMF p, IMD, IL12B, CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), IL-12/IL-23 p40, NK cell Stimulating Factor Chain 2, p40, Interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, IL 12B, IL12 p40, Interleukin 12 beta chain, Interleukin 12 p40 |
| Swissprot | |
| Cellular Localization | Secreted. |
| Concentration | 1.32 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:40-1:200 |
Background
Interleukin-12 (IL-12),is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs),including phagocytes,B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS),suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.