HBG1/HBG2 Polyclonal Antibody Reactivity Human
SKU: E-AB-52690-200
HBG1/HBG2 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52690 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human HBG1/HBG2 |
| Abbre | HBG1/HBG2 |
| Synonyms | A gamma globin, G gamma globin, Gamma 1 globin, Gamma 2 globin, Gamma A hemoglobin, Gamma globin, HBG 1, HBG 2, HBG1, HBG2, HBGA, HBGR, Hb F Agamma, Hb F Ggamma, Hemoglobin gamma, Hemoglobin gamma 1 chain , Hemoglobin gamma 2 chain , Hemoglobin gamma A, hbfagamma, hbfggamma |
| Swissprot | |
| Calculated MW | 16 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasmic |
| Concentration | 0.84 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cardiovascular |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:300 |
Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.