GLUT-4 Polyclonal Antibody Store at -20°C Host Rabbit
SKU: E-AB-30268-200
GLUT-4 Polyclonal Antibody Store at -20°C Host Rabbit
| SKU # | E-AB-30268 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Glut4. |
| Abbre | GLUT-4 |
| Synonyms | GLUT 4, GLUT-4, GLUT4, GTR4, Glucose transporter GLUT 4, Glucose transporter type 4, Glucose transporter type 4 insulin responsive, Insulin responsive glucose transporter type 4, SLC 2A4, SLC2A4, insulin-responsive, kug, solute carrier family 2 (facilitated glucose t |
| Swissprot | |
| Calculated MW | 55 kDa |
| Observed MW | 56 kDa |
| Cellular Localization | Cell membrane. Endomembrane system. Cytoplasm, perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-2000 |
| IHC | 1:50-300 |
Background
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).