FNIP2 Polyclonal Antibody
SKU: E-AB-19877-200
FNIP2 Polyclonal Antibody
| SKU # | E-AB-19877 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human FNIP2 |
| Abbre | FNIP2 |
| Synonyms | FNIP1-like protein, FNIP2, FNIPL, Fnip2, Folliculin-interacting protein 2, KIAA1450, MAPO1, O6-methylguanine-induced apoptosis 1 protein, OTTHUMP00000221326 |
| Swissprot | |
| Calculated MW | 122 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm. Co-localizes with FLCN in the cytoplasm. |
| Concentration | 1.14 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Metabolism, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin.