EDARADD Polyclonal Antibody Reactivity Human
SKU: E-AB-52310-200
NUDT18 Polyclonal Antibody
| SKU # | E-AB-52310 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Full length fusion protein |
| Abbre | EDARADD |
| Synonyms | Cr, Crinkled homolog, ED3, EDA3, EDAD, EDAR associated death domain, EDAR-associated death domain protein, EDARADD, Ectodysplasin-A receptor-associated adapter protein, Protein crinkled homolog, ectodysplasia A receptor associated death domain |
| Swissprot | |
| Cellular Localization | Cytoplasm. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:35-1:200 |
Background
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands.The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives.This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth.Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways.Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.