ECH1 Polyclonal Antibody Reactivity Human
SKU: E-AB-52890-200
ECH1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52890 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ECH1 |
| Abbre | ECH1 |
| Synonyms | 4)-dienoyl-CoA isomerase, 5)-Delta(2, Delta(3, Delta(3 5) Delta(2 4) dienoyl CoA isomerase, Delta(3 5) Delta(2 4) dienoyl CoA isomerase mitochondrial, Delta3 5 delta2 4 dienoyl CoA isomerase, Dienoyl CoA isomerase, ECH 1, ECH1, Ech1, En, Enoyl Coenzyme A hydratase 1 |
| Swissprot | |
| Calculated MW | 36 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Mitochondrion. Peroxisome. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Signal transduction, Tags and Cell markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:300 |
Background
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.