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CYP1A1 Polyclonal Antibody Store at -20°C
SKU: E-AB-14029-200
CYP1A1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-14029 |
| Reactivity | Human , Mouse , Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human , Mouse , Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CYP1A1 |
| Abbre | CYP1A1 |
| Synonyms | AHH, AHRR, Aryl hydrocarbon hydroxylase, CP11, CP1A1, CYP 1, CYP1, CYPIA1, Cytochrome P1 450 dioxin inducible, Cytochrome P1-450, Cytochrome P450 1A1, Cytochrome P450 family 1 subfamily A polypeptide 1, Cytochrome P450 form 6, Cytochrome P450 subfamily I (aroma, cyp1a1 |
| Swissprot | |
| Calculated MW | 58 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.