Crystallin-Alpha C Monoclonal Antibody
SKU: E-AB-22177-200
Crystallin-Alpha C Monoclonal Antibody
| SKU # | E-AB-22177 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein |
| Abbre | HSPB8/HSP22 |
| Synonyms | Alpha crystallin C chain, Alpha-crystallin C chain, CMT2L, CRYAC, Charcot Marie Tooth disease axonal type 2L, Charcot Marie Tooth disease spinal, DHMN 2, DHMN2, E2 induced gene 1 protein, E2-induced gene 1 protein, E2IG1, H11, Heat shock 22kDa protein 8, Heat shock 27 |
| Swissprot | |
| Observed MW | 22 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Translocates to nuclear foci during heat shock. |
| Tissue Specificity | Predominantly expressed in skeletal muscle and heart |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Clone No. | 2C3 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-2000 |
Background
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.