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APTX Polyclonal Antibody Store at -20°C
SKU: E-AB-10820-200
APTX Polyclonal Antibody Store at -20°C
| SKU # | E-AB-10820 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human APTX |
| Abbre | APTX |
| Synonyms | AOA, AOA 1, AOA1, APTX, AXA 1, AXA1, Aprataxin, Aprataxin homolog, Aptx, Ataxia 1 early onset with hypoalbuminemia, Ataxia1 early onset with hypoalbuminemia, EAOH, EOAHA, FHA HIT, FHA-HIT, FLJ20157, Forkhead associated doma, Forkhead associated domain histidine triad like |
| Swissprot | |
| Cellular Localization | Nucleus>nucleoplasm. Nucleus>nucleolus. Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.