ABI1 Polyclonal Antibody Store at -20°C
SKU: E-AB-12222-200
ABI1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-12222 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HTR1A |
| Abbre | HTR1A |
| Synonyms | 5 HT 1A, 5 HT receptor 1A, 5 HT1A, 5 HT1A receptor, 5 hydroxytryptamine (serotonin) receptor 1A, 5 hydroxytryptamine (serotonin) receptor 1A G protein coupled, 5 hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, 5-hydroxytryptamine receptor 1A, 5HT 1A, 5HT 1A receptor |
| Swissprot | |
| Calculated MW | 46 kDa |
| Cellular Localization | Cell membrane. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14