TRIM21 Polyclonal Antibody Store at -20°C
SKU: E-AB-15410-200
TRIM21 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15410 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human TRIM21 |
| Abbre | TRIM21 |
| Synonyms | 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, 52-KD, 52kD Ro/SSA autoantigen, Autoantigen Ro/SSA, E3 ubiquitin-protein ligase TRIM21, RING finger protein 81, RNF81, RO52, Ro 52, Ro(SS-A), Ro52, Sicca syndrome antigen A, Sjoegren syndrome type A anti |
| Swissprot | |
| Calculated MW | 54 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasm>P-body. Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-1:5000 |
Background
This gene encodes a member of the tripartite motif (TRIM) family.The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules.The RoSSA particle localizes to both the cytoplasm and the nucleus.RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.