First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Tribioscience XAV-939, Tankyrase Inhibitor
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Tribioscience XAV-939, Tankyrase Inhibitor
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
Molecular Formula: C14H11F3N2OS
Formula Weight: 312.31
CAS Number: 284028-89-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
Tankyrase inhibitor
Functions
Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes Wnt signaling downstream of receptor activation via stabilization of axin, a negative regulator of β-catenin. Robustly induces cardiomyogenesis of stem cells. Reduces experimental fibrosis in a mouse model of bleomycin-induced dermal fibrosis. Promotes apoptosis in a neuroblastoma cell line via telomere shortening. An important tool for probing the activation of the Wnt/β-catenin pathway in cells. Cell permeable.
Application Procedures