Product Details
Formal Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Formula: C20H16N2O4
Formula Weight: 348.40
CAS Number: 7689-03-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year
Applications
Topoisomerase I inhibitor
Functions
Camptothecin is a natural product isolated from Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I and binds irreversibly to the topoisomerase I /DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Induces apoptosis in a variety of cell lines and is a potent antitumor agent.
Application Procedures