Tribioscience Tozasertib, Aurora Kinase Inhibitor (TBI2178)

Tribioscience Tozasertib, Aurora Kinase Inhibitor (TBI2178)

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Product Details

Alternate Names: VX-680; MK-0457

Molecular Formula: C₂₃H₂₈N₈OS

Formula Weight: 464.59

CAS Number: 639089-54-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 100 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Aurora kinase inhibitor

Functions

Inhibitor of Aurora kinases. Blocks cell cycle progressing, inhibits proliferation, and induces apoptosis in a wide range of cancer cell lines (IC50 = <10 μM for clear cell renal carcinoma).

Application Procedures

First dissolved in DMSO (up to 100 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.