Texapon ASV is an anionic surfactant used in cosmetic products. It is certified as a benchmark reference substance for irritation evaluation of cosmetics in the Chorioallantoic Membrane (CAM) Assay.
This substance is used to determine the threshold between the irritation categories moderately irritating and irritating. The 5% active substance in Texapon ASV is a standard concentration since it has been assessed as moderately irritating in the Draize rabbit eye test.
The final irritation value is represented as quotients (Q) of the irritation indexes. Q=scoretest/scorestandard. The irritation score is shown below.
Applications
- HET-CAM Assay for Irritation Test.
- CAM-Vascular Assay (CAMV).
Table 1: Irritation Score for Test Material
| Irritation Score | Severity | Parameter |
|---|---|---|
| 0 | None | None |
| 1 | Slight | Haemorrhage and lysis |
| 2 | Moderate | Haemorrhage and lysis |
| 3 | Severe | Haemorrhage and lysis |
Table 2: The Criteria of Q Value for Irritating Severity
| Q Value | Irritating Severity |
|---|---|
| <1.2 | Non/Slight |
| ≥1.2 but <2 | Moderate |
| ≥2.0 | Severe |