First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
Tribioscience Tetrabenazine, VMAT2 Inhibitor; Stem Cell – Beta Cell Inducer (TBI2672)
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Tribioscience Tetrabenazine, VMAT2 Inhibitor; Stem Cell – Beta Cell Inducer (TBI2672)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: (3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
Molecular Formula: C19H27NO3
Formula Weight: 317.43
CAS Number: 58-46-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
VMAT2 inhibitor; stem cell – beta cell inducer
Functions
Potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM with selectivity for VMAT2 over VMAT1. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.
Application Procedures