Tribioscience TCID, DUB Inhibitor (TBI2428)

Product Details

Formal Name: 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione

Molecular Formula: C₉H₂Cl₄O₂

Formula Weight: 283.93

CAS Number: 30675-13-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: Room temperature

Stability: ≥ 1 year.

Applications

DUB inhibitor

Functions

Inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3).  IC50=0.6 µM, 125-fold selective over UCH-L1, IC50=75 µM.  Cell permeable.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.