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Tribioscience Tau(Phospho-Thr205) Antibody (TBS10047)
SKU: TBS10047-50UL
Tribioscience Tau(Phospho-Thr205) Antibody (TBS10047)
Description
The Tau (Phospho-Thr205) Antibody could play a role in the establishment and maintenance of neuronal polarity by promoting microtubule assembly and stability. It appears that tau serves as a linker protein between these processes, as the C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components. Tau localization inside the neuronal cell, specifically in the centrosome-defined area of the cell body, predetermines axonal polarity. While longer isoforms may primarily contribute to the stabilization of the cytoskeleton, shorter isoforms permit greater plasticity.
Product Details
Host Species: Rabbit
Clonality: Polyclonal
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications: WB IHC, ELISA
Species Reactivity: Hu Ms Rt
Specificity: The antibody detects endogenous level of Tau only when phosphorylated at threonine 205.
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of threonine 205 (P-G-T(p)-P-G) derived from Human Tau.
Accession No.: Swiss-Prot: P10636NCBI Protein: NP _001116538.1
Uniprot: P10636.
Concentration: 1.0mg/ml
Formulation: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Applications
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100