Product Details
Formal Name: N,N-Diethylaminoethyl-2,2-diphenylvalerate hydrochloride
Alternate Names: Proadifen
Molecular Formula: C23H31NO2 ∙ HCl
Formula Weight: 390.00
CAS Number: 62-68-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Cytochrome P450 inhibitor
Functions
Broad-spectrum cytochrome P450 monoxygenase inhibitor that also blocks the acetylcholine receptor (IC50 = 19 µM). Inhibits nitric oxide synthase (NOS). Also inhibits glibenclamide-sensitive K+ channels (IC50 = 9.8 µM) in Xenopus oocytes. Increases inflammatory cytokine expression in Müller glial cells and inhibits the excitability of rat 5-HT neurons.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.