First dissolved in DMSO (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Tribioscience SIC5-6, Separase Inhibitor (TBI4075)
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Tribioscience SIC5-6, Separase Inhibitor (TBI4075)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 3,3’-(1-((4-Iodophenyl)sulfonyl)piperidine-4,4’diyl)bis(1H-indole)
Molecular Formula: C27H24IN3O2S
Formula Weight: 581.47
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Separase inhibitor
Functions
Inhibitor of separase (a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers), but not the related protease caspase-1, in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target.
Application Procedures