Description
Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic effects on various cell types and is a major regulator of inflammatory responses. Structurally, TNF-α is a homotrimer protein consisting of 157 amino acids, primarily produced by activated macrophages, T-lymphocytes, and natural killer cells, neutrophils, CD4+ T cells, LAK cells. TNF-α plays a significant role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. TNF-α is involved in both promoting and inhibiting tumor progression, depending on the context and the interaction with its receptors.
Product Details
Molecular Weight: 17.5 kDa
Formulation: Liquid in. Phosphate-Buffered Saline (pH 7.4)
Purity: > 95% by SDS-PAGE
Application: SDS-PAGE, Bioactivity
Storage Condition: Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.