Tribioscience Pioglitazone HCl, PPARg Agonist (TBI1010)

Tribioscience Pioglitazone HCl, PPARg Agonist (TBI1010)

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Product Details

Formal Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride

Molecular Formula: C₁₉H₂₀N₂O₃S ∙ HCl

Formula Weight: 392.90

CAS Number: 112529-15-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

PPARg agonist

Functions

Pioglitazone is a clinically useful antidiabetic drug. It is a selective agonist of the human peroxisome proliferator-activated receptor γ1(PPARγ1; EC50 = 490 nM2, 550nM3) with weak agonist activity at PPARα and no activity at PPARδ.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.