Product Details
Formal Name: 2-(4-Pentylcinnamoyl)amino-4-chlorobenzoic acid
Alternate Names: PACA
Molecular Formula: C21H22ClNO3
Formula Weight: 371.86
CAS Number: 99754-06-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Phospholipase A2 inhibitor
Functions
Reversible inhibitor of Ca2+-independent phospholipase A2 (PLA2), IC50=7 μM for guinea pig lung PLA2. Inhibits epinephrine-induced thromboxane production in platelets. Inhibition of PLA2 by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex. Prevents Xenopus oocyte maturation at stage V.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.