Product Details
Formal Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Alternate Names: F6
Molecular Formula: C21H21NO · HCl
Formula Weight: 339.86
CAS Number: 157654-67-6
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 8 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
DUB inhibitor
Functions
A pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway. Cell permeable..
Application Procedures
First dissolved in DMSO (up to 8 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.