First dissolved in DMSO (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 week.
Tribioscience Nitazoxanide, Wnt Inhibitor; Antiviral (TBI4633)
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Tribioscience Nitazoxanide, Wnt Inhibitor; Antiviral (TBI4633)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate
Molecular Formula: C12H9N3O5S
Formula Weight: 307.28
CAS Number: 55981-09-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Wnt inhibitor; Antiviral
Functions
Nitazoxanide is a clinically relevant antiparasitic agent.1It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, Hepatitis B and C, RSV, coronavirus, dengue and others.2 Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases.3 Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α).4 Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC) – it targets peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin.5
Application Procedures