Product Details
Formal Name: 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
Alternate Names: ML414
Molecular Formula: C17H22N4O3S2
Formula Weight: 394.51
CAS Number: 790702-57-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Oligosaccharyltransferase (OST) inhibitor
Functions
NGI-1 is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 µM. It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika). It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.