Product Details
Formal Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Alternate Names: AF1890; Diclondazolic acid
Molecular Formula: C15H10Cl2N2O2
Formula Weight: 321.20
CAS Number: 50264-69-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Inhibits cancer cell metabolism
Functions
Indazole-3-carboxylic acid derivative that inhibits mitochondria-bound hexokinase, reducing aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells (IC50 = 90 and 45 µM, respectively). Causes intracellular acidification by inhibition of lactate transport. Also inhibits the mitochondrial pyruvate carrier (Ki 2.5 μM) and monocarboxylate transporter isozymes, as well as the succinate-ubiquinone reductase activity of respiratory complex II. Enhances infection by oncolytic M1 virus via downregulation of antiviral immune response.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.