Product Details
Formal Name: 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
Alternate Names: O6-(4-Bromothenyl)guanine
Molecular Formula: C10H8BrN5O3S
Formula Weight: 326.20
CAS Number: 192441-08-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
MGMT inhibitor
Functions
Lomeguatrib is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein. It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.