Product Details
Formal Name: 4-guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate
Alternate Names: SCM-198
Molecular Formula: C14H21N3O5
Formula Weight: 311.33
CAS Number: 24697-74-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Neuroinflammation inhibitor
Functions
Inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways. Inhibits the formation of advanced glycation end products. Ameliorates cognitive dysfunction by antagonizing exocytotoxic glutamate insults and inhibiting autophagy. Attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4. Attenuates early atherosclerotic lesions in hypercholest-erolemic rabbits via modulation of the inflammatory and oxidative stress pathways.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.