Product Details
Formal Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
Alternate Names: Lylamine HCl; (+)-Dehydroabietylamine HCl
Molecular Formula: C20H31N • HCl
Formula Weight: 321.90
CAS Number: 16496-99-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Intracellular cholesterol inhibitor
Functions
A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux. Induces apoptosis in breast cancer, melanoma and prostate cancer cells. A selective inducer of cytochrome P450 2B. Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.