First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in
DMSO or ethanol may be stored at -20°C for up to 3 months.
Tribioscience HPA (Hexyl-4-Pentynoic Acid), HDAC Inhibitor (TBI1160)
SKU: TBI1160-20MG
Tribioscience HPA (Hexyl-4-Pentynoic Acid), HDAC Inhibitor (TBI1160)
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Product Details
Formal Name: 2-(2-Propynyl)octanoic acid (racemic)
Alternate Names: HPA
Molecular Formula: C11H18O2
Formula Weight: 182.27
CAS Number: 96017-59-3
Purity: >98%
Formulation: oil
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
HDAC inhibitor
Functions
Histone deacetylase (HDAC) inhibitor, IC50=13 µM. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 µM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons. Cell permeable.
Application Procedures