First dissolved in DMSO (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Herbimycin A, HSP90 Inhibitor; Src Inhibitor (TBI2567)
SKU: TBI2567-100UG
Tribioscience Herbimycin A, HSP90 Inhibitor; Src Inhibitor (TBI2567)
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Product Details
Formal Name: (15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Molecular Formula: C30H42N2O9
Formula Weight: 574.68
CAS Number: 70563-58-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 6 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
HSP90 inhibitor; Src inhibitor
Functions
Ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity. Inhibits angiogenesis in a rat retinopathy model.
Application Procedures