Tribioscience GW-9662, PPARg Antagonist (TBI2622)
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Tribioscience GW-9662, PPARg Antagonist (TBI2622)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 2-Chloro-5-nitrobenzanilide
Molecular Formula: C13H9ClN2O3
Formula Weight: 276.68
CAS Number: 22978-25-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
PPARg antagonist
Functions
Selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM). Displays anticancer activity inhibits growth of human mammary tumor cell lines. A useful tool for dissecting the involvement of PPARγ in cellular physiology.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.