Tribioscience Glumetinib, C-Met Inhibitor (highly Selective) (TBI4690)

Product Details

Formal Name: 6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine

Alternate Names: SCC244

Molecular Formula: C₂₁H₁₇N₉O₂S

Formula Weight: 459.50

CAS Number: 1642581-63-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

c-Met inhibitor (highly selective)

Functions

Highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.  It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer.