Product Details
Formal Name: (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine, hydrochloride
Alternate Names: LY-110,140
Molecular Formula: C17H18F3NO ∙ HCl
Formula Weight: 345.79
CAS Number: 56296-78-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml)
Storage: RT
Stability: ≥ 2 years.
Applications
Serotonin reuptake inhibitor (SSRI)
Functions
A selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 mM) transporters. A clinically useful antidepressive agent. Has shown some potential in autism spectrum disorders. Attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage. Orally active and active in vivo. Increases proliferation of neuronal precursors derived from human embryonic stem cells, inducing differentiation and strongly enhancing neuronal characteristics.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.