First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.
Tribioscience FH-53Embelin, XIAP Inhibitor; Apoptosis Inducer (TBI2959)
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Tribioscience FH-53Embelin, XIAP Inhibitor; Apoptosis Inducer (TBI2959)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
Molecular Formula: C17H26O4
Formula Weight: 294.39
CAS Number: 550-24-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
XIAP inhibitor; Apoptosis inducer
Functions
Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.
Application Procedures