Product Details
Formal Name: 1-(2-Thiazolylazo)-2-naphthol
Alternate Names: NSC139021
Molecular Formula: C13H9N3OS
Formula Weight: 255.30
CAS Number: 1147-56-4
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to at least 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Highly selective ERG inhibitor
Functions
ERGi-USU selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
Application Procedures
First dissolved in DMSO (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.