Product Details
Formal Name: N’1,N’3-Dimethyl-N’1,N’3-di(phenylcarbonothioyl)malonohydrazide
Alternate Names: STA-4783; GSK842879A
Molecular Formula: C19H20N4O2S2
Formula Weight: 400.50
CAS Number: 488832-69-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Copper chelator/Cuproptosis inducer
Functions
Elesclomol induced oxidative stress in cancer cells via rapid generation of reactive oxygen species. It preferentially binds copper ions outside the cell and selectively transports inside the mitochondria with subsequent reactive oxygen species generation leading to apoptosis. Elesclomol can restore copper homeostasis in models of copper deficiency and disorders of copper metabolism. Copper-induced cell death (Cuproptosis) caused by Elesclomol is now believed to occur via direct binding of copper to lipoylated components of the tricarboxylic acid cycle causing protein aggregation and subsequent iron-sulfur protein loss leading to proteotoxic stress and cell death.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.