Product Details
Formal Name: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Alternate Names: PF-02341066; PF-1066
Molecular Formula: C21H22Cl2FN5O
Formula Weight: 450.34
CAS Number: 877399-52-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
c-MET and ALK inhibitor
Functions
A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively. Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells. Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms. Clinically useful anticancer agent.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.