Product Details
Formal Name: (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt
Alternate Names: MK 0791
Molecular Formula: C16H25N2O5S Na
Formula Weight: 380.43
CAS Number: 81129-83-1
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Dipeptidase inhibitor; DPEP1 inhibitor
Functions
Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4. Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics. Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria. Suppresses invasion and metastasis of DPEP1-expressing tumor cells.
Application Procedures
First dissolved in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.