Tribioscience CD38 (Cyclase) Activity Assay Kit (Fluorometric) (TBS2100)

Tribioscience CD38 (Cyclase) Activity Assay Kit (Fluorometric) (TBS2100)

Buy Tribioscience products from MSE Supplies at the best value. 

CD38, also known as ADP-ribosyl cyclase, is a multifunctional ectoenzyme expressed in many immune cells including CD4+, CD8+, B lymphocytes and natural killer cells. It functions in cell adhesion, signal transduction and calcium signaling. CD38 is involved in the metabolism of nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP). The results are the production of Ca2+-mobilizing compounds, such as cyclic ADP ribose (cADPR) and ADP ribose (ADPR). CD38 is used as a marker for poor prognosis in chronic lymphocytic leukemia and multiple myeloma and is an attractive cancer immunotherapy drug target.

Tribioscience’s CD38 Assay Kit is a simple and fast fluorometric assay that measures the cyclase activity of CD38 in biological samples. CD38 catalyzes the conversion of nicotinamide guanine dinucleotide (NGD+) to cyclic GDP-ribose (cGDPR) which can be measured by fluorometric method at Ex/Em=300 nm/410 nm.

Applications

• Measure CD38 Cyclase activity in a variety of samples.

Storage Conditions

Store the Reagent at -20°C, protect it from light. Shelf life: 12 months.

For Research Use only

Standard Curve